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KMID : 1123920040180030857
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 3 p.857 ~ p.862
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Effect of Kamichungbieum on Allergic Reaction
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Kim Kwang-Sik
Lee Dong-Hee
Kwon Young-An
Choi Suh-Young
Eun Jae-Soon
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Abstract
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The purpose of this research was to investigate the effects of supercritical fluid extract of Kamichungbieum (SFE) on allergic reaction. SFE (500 mg/kg) inhibited the systemic anaphylaxis induced by compound 48/80 or platelet activating factor and inhibited the passive cutaneous anaphylaxis (PCA) induced by anti-dinitrophenyl (DNP)-lgE and DNP-human serum albumin (HSA) in vivo. Also, SFE inhibited the SRSC-induced delayed type hypersensitivity and inhibited the hind paw edema induced by histamine. In addition, SFE inhibited the permeability of evans blue induced by acetic acid and inhibited the writhing syndrome induced by acetic acid. These results indicate that SFE may be useful for the prevention and treatment of allergy related disease.
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KEYWORD
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Kamichungbieum(加味淸鼻飮), supercritical fluid extract, compound 48/80, PCA, DNP-lgE, writhing syndrome
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